With the increase in popularity for Axxie’s as a pet species, it becomes imperative to offer these amphibians the best in standards of care. The great news is that we have a lot of information about them from our lab animal practitioner friends! This review serves to give an overview of evidenced-based approaches to physical exam, diagnostics, disease management, husbandry recommendations, and how to outfit your practice to see them as emergent cases. A reference list will be provided for independent study and articles available at request onsite.