The purpose of this lecture is to equip veterinary professionals, particularly those working in emergency and critical care settings, with the knowledge and skills necessary to identify, diagnose, and manage anaphylactic reactions in dogs and cats. We will review the pathophysiology, clinical presentation, diagnostic criteria, differential diagnoses, and effective treatment protocols for anaphylaxis in veterinary patients, with a focus on evidence-based, real-world approaches. Through case discussions and a step-by-step review of treatment protocols, attendees will gain insights into the complexities of managing these high-stakes clinical scenarios in a fast-paced ER environment.