During this lecture the audience will learn about non-NSAID, non-opioid oral pain modifying analgesic drugs (PMAD) and their use in clinical practice for chronic pain. Examples include but are not limited to tramadol, gabapentinoids, amantadine, amitriptyline, SSNRIs, CBD Learning Objectives: 1. Gain understanding of adjunctive PMAD mechanisms of action 2. Learn patient populations that would most benefit – or not benefit – from various adjunctive oral PMADs. 3. Understand clinical use of various oral PMADs