The distinction between central and peripheral vestibular disease is critical because the prognosis and treatment are so different. This talk will focus on the identification of central lesions as compared to peripheral lesions and their treatment. Encephalitis is a common cause of central vestibular disease. Typically, this is from a non-infectious cause with current nomenclature favoring the term Meningoencephalomyelitis of Unknown Etiology (MUE) – this disease will be discussed in this talk. Objective: Attendees will emerge confident in their ability to localize vestibular lesions, as well as the identification and treatment of dogs with suspected MUE.