Elasmobranchs include the sharks, rays, skates, sawfish and guitarfish. Elasmobranchs have several anatomical structures that differ from teleosts (bony fish): These fish have cartilaginous skeletons, no swim bladder, and a branchial corpus cavernosum that provides blood and hydraulic support to the filaments. These fish do not have adipose tissue, and store lipid in hepatocytes. The epigonal and Leydig organs are the sites of hematopoiesis. Elasmobranchs have dermal denticles, modified scales that cover the epidermis, that have the same embryologic origin as teeth. Remarkably, in captive care the various elasmobranchs share many of the same disease processes. This presentation will concentrate on the commonly encountered diseases of these fish, including infectious diseases, developmental anomalies, nutritional, metabolic, degenerative, depositional, neoplastic and traumatic diseases.