Effective surgical pain management is crucial for patient outcomes, but protocols for exotic mammals often fall behind those for traditional species. This masterclass will review current best practices in preemptive, intraoperative, and postoperative analgesia tailored to rabbits, rodents, and ferrets. Topics include multimodal pain management, species-specific opioid and NSAID use, local blocks, CRIs, and the role of non-pharmacologic adjuncts.