Dental disease is a common disorder affecting domestic rabbits, yet its underlying etiologies remain incompletely understood. While insufficient occlusal wear is a well-recognized cause, a proposed mechanism of metabolic bone changes may predispose rabbits to dental pathology. This study aimed to determine whether quantitative cone beam computed tomographic analysis of the calvarial bones can identify differences between rabbits with and without dental disease, thereby exploring the possibility of a broader metabolic component. Cone-beam CT scans from a single exotic animal practice (2020–2025) were reviewed, yielding 37 rabbits with confirmed dental disease and 42 controls without cranial pathology. Regions of interest were placed on the frontal, parietal, and occipital bones, and greyscale values were recorded. Demographic variables (age, sex, altered status, weight) were also collected. Results and conclusions will be presented.