Geriatric ferrets often present with vague or overlapping clinical signs that can make diagnosis challenging. In this lecture, we’ll focus on recognizing and managing the three most common diseases affecting aging ferrets: adrenocortical disease, insulinoma, and lymphosarcoma. We’ll review both common and subtle clinical signs as well as classic presentations such as the “flat-out ferret.” Emphasis will be placed on distinguishing these conditions from other common ferret diseases and recognizing when multiple disease processes may be present. Diagnostic approaches will focus on accessible tools including physical exam findings, basic laboratory evaluations, imaging, and selective advanced diagnostics. Current management strategies for each condition will be reviewed, including indications, limitations, and expected outcomes for each. Through practical discussion, this session will support more consistent, confident clinical decision-making when managing these common ferret diseases.