A 2-year-old male neutered ferret (Mustela putorius furo) presented to [redacted] for anorexia, lethargy, listlessness, and weakness. On presentation, the patient was obtunded, recumbent, and bradycardic with absent palpebral reflexes bilaterally, horizontal nystagmus, and delayed withdrawal reflexes in the hindlimbs. MRI of the head revealed a right-sided extra-axial abscess associated with right-sided otitis media and interna causing cerebral compression and caudal cerebellar herniation. A right transtentorial craniectomy and right total ear canal ablation and ventral bulla osteotomy were performed. Culture and sensitivity results revealed Staphylococcus aureus infection and antimicrobial therapy with clindamycin and enrofloxacin was instituted. Histopathology of removed bone revealed cholesteatoma. The patient showed improvement in neurologic status on levetiracetam until two months postoperatively when he became acutely ataxic and had a suspected seizure. Repeat head MRI showed recurrent right-sided intracranial abscess with cerebral compression, meningitis, recurrent otitis media and interna with abscessation into surrounding soft tissues, and caudal cerebellar herniation. Culture showed recurrent Staphylococcus aureus infection. The excision of the remainder of the right ear canal, right pinnectomy, and total bulla ablation were performed and the soft tissue abscess was surgically drained. Trimethoprim-sulfamethoxazole was added to the antimicrobial regime. Repeated abscessation of the surgical site and occasional seizures were managed with abscess drainage and marsupialization, changes in antimicrobial therapy, and replacement of levetiracetam with phenobarbital. The ferret died suddenly 12 months after the initial diagnosis. This is the first reported case of craniectomy for intracranial abscessation achieving long-term survival in a ferret .