This interactive masterclass will provide a concise overview of current knowledge on reptile sedation, regional anesthesia, general anesthesia, and analgesia. Attendees will learn about clinically relevant anatomy and physiology, commonly used drugs and protocols, regional anesthesia techniques, and current analgesic recommendations. In addition, clinical case examples will be used to allow attendees to apply and challenge their knowledge. This masterclass will be co-presented by two instructors to make this session more interactive.