Atadenovirus infection in bearded dragons (Pogona vitticeps) remains one of the most commonly identified viral findings in captive reptiles, yet its clinical significance is often overstated. Despite decades of investigation, Koch’s postulates have not been fully satisfied for this virus in Pogona. As a result, the presence of Atadenovirus does not independently confirm causation of gastrointestinal, hepatic, or neurologic disease. High prevalence in asymptomatic animals, inconsistent association with lesions, and the influence of multiple husbandry and comorbidity factors complicate interpretation. This lecture will provide reptile clinicians with an updated, evidence-based framework for approaching Atadenovirus cases in practice. Topics include current prevalence data; pathophysiologic hypotheses; limitations of PCR and histopathology; and the roles of coinfections (e.g., adenovirus + coccidia), early life stress, nutritional deficiencies, poor UVB quality, and immune compromise in the development of clinical illness. Case-based examples will demonstrate why a positive PCR result should not automatically prompt depopulation, euthanasia, or client panic, and how supportive care, environmental optimization, and management of concurrent conditions often yield favorable outcomes. Emphasis will be placed on practical clinical guidance: when to test, how to communicate results to clients, what prognostic factors truly matter, and how to counsel breeders and rescue organizations regarding biosecurity without reinforcing outdated or fear-driven recommendations. Attendees will leave with a clear, rational decision-making model for Atadenovirus that aligns with current evidence and supports patient welfare, clinician confidence, and client understanding.