This case describes the medical management of a strangulation wound in an Indian Rock Python (Python molurus). The python weighing 10 kilograms was rescued as it became entangled in an abandoned fishing net. The python sustained extensive deep injuries in the proximal portion of the body, leaving internal muscles exposed. The treatment regimen included fluids, antibiotic, wound flushing and freshening, and feeding, over a period of three months. The python responded well, and the development of granulation tissue was noted. Eventually, when the wound size reduced and muscular tissue was completely covered, the snake was released back into its natural habitat. Indian Rock Pythons face numerous threats like habitat loss and being poached for their skin. They’re also occasionally killed out of fear, or retaliation for loss of livestock. Moreover, incidents like entanglement in fishing nets and other human-made debris pose significant risks. While protected under Schedule I (Part C) of the Wildlife Protection Act, 1972 of India, the increasing anthropogenic pressures highlight the need for continued conservation efforts. Ultimately, effective veterinary intervention, along with awareness and stronger wildlife protection measures may augment the long-term survival of this species.