Nannizziopsis are keratinophilic fungi that infect reptiles and humans. N. arthrosporioides has caused infection in an African side-necked turtle (Pelomedusa subrufa), a Cuban rock iguana (Cyclura nubile), a Thai water dragon (Physignthus spp.), and a human, while outbreaks have been reported in ball pythons (Python regius) and leopard geckos (Eublepharis macularius). This study aimed to investigate the efficacy of a commercially available disinfectants against the growth of N. arthrosorioides. Two molecularly confirmed isolates of N. arthrosporioides were used. Hyphae was collected, filtered then diluted to 100,000 and 1,000 conidia/mL, representing high and low fungal concentrations, respectively. Each fungal suspension was mixed with an equivalent volume of sterile water (control), F10 SC at recommended product labels (1:100, 1:250), diluted commercial bleach (10%, equivalent to 0.74% hypochlorite), 409 multipurpose cleaner, chlorhexidine 2% solution, povidone iodine 10% solution, and Rescue Disinfectant (0.5% hydrogen peroxide). Exposure times of 5 or 10 minutes were allowed before the mixture was centrifuged and the supernatant removed. The fungal pellet was resuspended and plated onto potato dextrose agar, utilizing a technical repeat designed. The plates were sealed and allowed to incubate for 10 days before the plates were visually evaluated for the presence of absence of characteristic growth of N. arthrosorioides. Preliminary results indicate that 10% commercial bleach is an effective disinfectant for N. arthrosorioides.