Uveitis is the term for inflammation within the uveal tract, which is made up of the iris, the ciliary body, and/or the choroid. This is a condition that can occur in one or both eyes at the same time and can be painful and vision-threatening for the patient. Uveitis can develop as a primary ocular condition, or secondary to systemic diseases such as sepsis or neoplasia. Ocular disease can vary in severity, but in some cases, delays in treatment can lead to loss of vision or even the need to enucleate an affected eye. The goal of this presentation is to review the clinical signs, diagnostic approach, and treatment plan for some of the more common causes of uveitis in our exotic companion species including, but not limited to, ocular trauma, Encephalitozoon cuniculi, cataracts, and infections.