Objective: To describe the context and the techniques used during cystotomies in ferrets in Quebec (Canada) as well as determine the commonly used perioperative diagnostic tests and the surgical complications encountered. Methods: The medical files of 43 ferrets with a history of cystotomy, spanning from 2017 to 2023, amongst five veterinary hospitals in Quebec (Canada) were analysed retrospectively. The patients included in the study were identified by research of the billed items (cystotomy). Results: A significant difference in the distribution of sexes (P = 0,001) was observed with 32/43 (74%) ferrets being males, including 18/32 (56%) male ferrets with a calculi analysis confirming the presence of cystine urolithiasis. The median surgical time was 70 minutes. Minor complications developed in 14/38 cases (37%), whereas 8/38 (21%) ferrets having undergone a cystotomy developed a major complication. The most common major complication was found to be the incomplete removal of uroliths (4/38 cases; 10,5%). Clinical relevance: Uroliths are often encountered in ferrets and cystotomy is commonly chosen as the treatment to remove these stones. This study observed that cystotomies performed in ferrets have a similar median surgical time and similar minor complication rate as what has previously been described in dogs and cats. However, the major complication rate is higher than that of companion animals. Additional studies are needed to confirm these findings on a larger scale. This presentation will allow veterinarians to be more equipped to advise owners of the possible risks of performing cystotomy in ferrets.