Feline herpesvirus type-1 (FHV-1) is the most common type of viral infection in domestic cats and causes feline rhinotracheitis. Its transmission to exotic species can pose an important threat to animal health and the ecosystem. This case elaborates on the FHV-1 infection in a fennec fox (Vulpes zerda), an exotic desert animal imported to Pakistan recently. The fox presented to the clinic with clinical signs of nasal discharge, sneezing and lethargy. Upon check-up, the owner confirmed that he kept the fox with domestic cats that licked and groomed the fox, likely causing a viral infection. Viral isolation and histopathological examination showed FHV-1 infection. The foxes have mild interstitial pneumonia and non- suppurative rhinitis which are not mostly common in cats with FHV-1 infection. Genetic sequencing of the viral genes showed a close resemblance to FHV-1 strains found in domestic cats, which supports the hypothesis of species-to-specie transmission. The case demonstrates the risk of transmission of pathogens between domestic cats and exotic species which can later impact the biodiversity. Health screening and strict quarantine measures should be taken for exotic animals, as well as educating the pet owners to not keep the domestic and exotic pets together. This is 1st case of FHV-1 infection in fennic foxes describing the ability of cross-species viral transmission. More protective measures and studies are required to prevent the risk of FHV-1 transmission and ensure the health of wild and exotic species.