The rabbits’ light skeleton, relatively large muscle mass, and unique behaviors are considered predisposing factors for bone fractures. Yet evidence-based treatment guidelines for pet rabbits are currently lacking. Specifically, management of rabbit craniomaxillofacial orthopedic injuries are uncommonly reported. Diagnosis and management of craniomaxillofacial trauma in any species can be challenging. In addition to the complex architecture of bones within this region, important structures such as the brain, teeth, nasal cavity, paranasal sinuses, orbit, and various cranial nerves and vasculature are in close proximity. As such, craniomaxillofacial orthopedic injuries in the rabbit may be easily overlooked, or misdiagnosed as neurological, odontogenic, gastrointestinal, or even respiratory disease. A recent case series of rabbit maxillofacial fractures showed that prompt diagnosis and early functional recovery were paramount in the successful management of these injuries. Management strategies for craniomaxillofacial orthopedic injuries in dogs and cats may not be appropriate for rabbits due to differences in their anatomy, biomechanics, and physiology. Careful consideration to maintain odontogenic and gastrointestinal health in the rabbit is necessary to minimize secondary complications that can increase morbidity and mortality. Specific injuries such as mandibular symphyseal separation and temporomandibular joint luxation require species-specific techniques to achieve reduction and stabilization, which can be important for functional recovery. Techniques to achieve this are infrequently described, and will be covered by the authors in this masterclass. Real-life case scenarios will additionally be presented to help illustrate the various considerations required and treatment options available to help participants successfully navigate rabbit craniomaxillofacial orthopedic injuries.