Antimicrobial resistance (AMR) is a public health concern as there is a risk of zoonotic transmission of antimicrobial-resistant bacteria via direct contact with pets. Inappropriate antimicrobial usage, can lead to the selection of bacteria with acquired resistance and the development of multidrug-resistant pathogens. To reduce the risk of treatment failure and AMR, culture and sensitivity (C+S) is recommended prior to commencing treatment. However, empirical therapy, based on likely pathogens and susceptibility patterns is often started while these results are pending. The aim of this presentation is to (i) discuss common bacterial pathogens isolated from rabbits, specifically from infections located within the head and (ii) to discuss antimicrobial resistance in the most common aerobic bacterial pathogens isolated. Medical records for all rabbits with cultures from ear abscesses, dental abscesses, upper respiratory infections or nasolacrimal duct infections were examined from two private referral veterinary hospitals in Sydney, NSW, Australia between 2018 and 2024. Of the 91 samples collected, 89.0% (81/91) were positive. Of these positive samples, sensitivity was performed on 72 samples. The most commonly isolated aerobic bacteria were Staphylococcus, Streptococcus, Pseudomonas, Enterobacter and Escherichia. Resistance patterns among these pathogens was assessed for penicillin, TMS, chloramphenicol, enrofloxacin and marbofloxacin as these are amongst the most commonly prescribed antimicrobials used in rabbits. Understanding the common bacterial pathogens and likely resistance patterns associated with infections in the rabbits is crucial when prescribing antimicrobial therapy. Antimicrobials should be selected based on their importance rating, susceptibility and efficacy as well as prescribed for an appropriate duration.