This retrospective study examines allogenic whole blood transfusions in domestic rabbits (Oryctolagus cuniculus) over a 20-year period at a single veterinary institution, focusing on clinical indications, methods, outcomes, and complications. The study identifies the most common reasons rabbits require blood transfusions (such as liver lobe torsion, anemia or per-operative bleeding) and survival outcomes. While transfusions were generally well-tolerated, the study highlights potential adverse reactions and evaluates outcomes in cases with and without cross-matching. The findings highlight the importance of blood transfusions as a life-saving treatment in rabbits, while emphasizing the need for careful monitoring and standardized protocols to minimize complications.