A 9-year-old female-spayed rabbit (Oryctolagus cuniculus) initially presented as a referral for chronic rhinitis, head tilt, and an abdominal mass. Physical examination noted a large cranial abdominal mass. A complete blood count and biochemistry panel revealed hypercalcemia, but was otherwise unremarkable. Computed tomography (CT) scan confirmed the large, mid-abdominal fluid-filled, cyst-like structure suspected to be associated to the liver. Cytology of the cyst revealed marked calcification, and the culture of the fluid was negative. A laparotomy and surgical mass removal was performed, and histopathology confirmed biliary in origin. A recheck evaluation two weeks later noted splaying of all limbs. Repeat bloodwork showed progressive hypercalcemia and mild azotemia. The patient presented again 4 days with an acute left femur fracture and severe diffuse osseous remodeling in radiographs. Euthanasia was elected. Post-mortem evaluation revealed a parathyroid gland adenoma, severe diffuse fibrous osteodystrophy, moderate interstitial nephritis and fibrosis, and severe metastatic mineralization of multiple organs. This case illustrates a rare presentation and progression of a case of fibrous osteodystrophy and metastatic mineralization associated with a parathyroid adenoma in a rabbit.