Two pediatric small mammals, a ferret (Mustella putorius furo) and a rabbit (Oryctolagus cuniculus) were respectively diagnosed with a humeral and a femoral fracture. Safety Pin Tie In, a type I stainless steel fixator without proximal transfixion pin, was used to stabilize the fracture in both individuals. Clinical examination, including lameness evaluation and bone callus palpation, as well as radiographical images were followed-up. Complete osteosynthesis and implant removal were achieved in both cases after 4 weeks. The 2 cases were followed-up 12 months after the surgery, and both patient recovered normal locomotor function. Based on the results of this case report, Safety Pin Tie In appears as a promising, minimally invasive option for humeral and femoral fractures in growing small mammals. Despite the absence of a proximal transfixion pin, it provides satisfying biomechanical stability for obtaining biological osteosynthesis. This technique reduces surgical trauma and preserves the callus environment, critical for healing. Further studies are needed to validate these findings.