Background: To compare invasive arterial blood pressure, considered gold standard for measuring blood pressure in rabbits, with a high-definition oscillometric device (Suntech Vet30). Methods: Twenty New-Zealand white rabbits were anesthetized with a protocol developed and overseen by a senior clinician in veterinary anesthesiology. Arterial catheterization was performed in every patient. Non-invasive measurements were performed at the forelimb and hindlimb under hypotensive and normotensive situations. Simultaneous measurements of invasive blood pressure (IBP) and non-invasive blood pressure (NIBP) were recorded. The difference between the two methods was compared between normotensive and hypotensive situations using a paired-sample t-test. Lin’s concordance correlation coefficient and Bland-Altman plots were performed to assess agreement between IBP and NIBP measurement methods. Results: There was no significant difference (p > 0.05) for any tested parameter when comparing between the two situations. Results for Lin’s concordance correlation coefficient were considered inacceptable (< 0.5) for all tested parameters. Bland-Altman plots showed NIBP overestimates IBP by particularly far concerning systolic blood pressure for all parameters (systolic, diastolic and mean) and at both evaluated sites. A clear tendency was observed with NIBP overestimated more severely the IBP when increasing blood pressure. Limitations: The oscillometric device tested only have a software for dogs and cats installed. This study should be repeated when a future software specific to the rabbit is developed. Conclusion: This high definition oscillometric monitor should not be used for monitoring blood pressure in anesthetized rabbits.