Liver lobe torsion is potentially fatal condition in rabbits, often necessitating diagnostic imaging such as ultrasonography or CT scan for confirmation. Surgical intervention is frequently required for optimal outcomes. Renal cysts are uncommon in rabbits, making this case particularly unique. This case study describes the successful management of concurrent liver lobe torsion and severe multiple renal cysts in a single rabbit. A 2-year-old spayed female Mini Rex rabbit weighing 1.33 kg with a body condition score of 2/5 presented with acute anorexia, depression, and reduced fecal output. Ultrasound imaging revealed dilated left ureter and renal pelvis with multiple cysts, alongside heterogeneous parenchymal echogenicity of the caudate liver lobe with no Doppler signal detected. Emergency surgery, comprising hepatic lobectomy and nephroureterectomy, was performed, accompanied by blood transfusion immediately. Postoperative management included pain control, monitoring of blood chemistry parameters, and clinical presentation resulting in subsequent normalization. Ongoing follow-up is essential to assess for complications, such as renal insufficiency or hepatitis. This case adds to our understanding of managing complex conditions in rabbits and underscores the importance of a comprehensive approach to optimize clinical outcomes.