Whipworm infection is caused by a parasitic eukaryotic nematode belonging to the genus Trichuris. Infections range from subclinical disease to more severe clinical signs, including frequent and painful defecation, bloody diarrhea, and vomiting. Due to the long life cycle of this parasite, treatment must extend over many months and, thus, re-infections are common. There are several species within the genus, Trichuris with a broad host range, capable of infecting a variety of domestic and exotic animals. Notably, the species Trichuris trichiura is zoonotic, infecting both human and non-human primates. Despite their importance, there is limited knowledge about the effects of T. trichiura infection and whipworm treatment on the microbiome of infected baboons. Additionally, due to difficulty of sequencing Eukaryote parasite genomes, little is known about changes in the T. trichiura genome in response to antiparasitic drugs like albendazole. This study will examine a population of 14 Hamadryas baboons (Papio hamadrayas) from the Oakland Zoo and screen them for T. trichiura. Fecal samples from the baboons will be collected monthly for three months during albendazole treatment and submitted for shotgun sequencing and metagenomic analysis. Genomes of T. trichiura will be assembled and compared throughout timepoints to investigate the impact of albendazole on the parasite’s progression and evolution. Additionally, microbiome analysis will be performed from the metagenome sequence data to assess the changes in the gut microbiota from antiparasitic drugs over time.