Acute appendicitis is a common but often underdiagnosed condition in rabbits, frequently misdiagnosed as gastrointestinal stasis. This study aimed to evaluate the efficacy of medical management in rabbits with acute appendicitis. Medical treatment included fluid therapy, antibiotics, analgesics, anti-inflammatories, and assisted feeding. Appendicitis in rabbits is primarily associated with an inadequate diet, intestinal parasitosis, and predisposing factors such as obesity, dehydration, and thermal stress. Clinical signs are often nonspecific, including anorexia, lethargy, abdominal pain, and hyperthermia. The diagnosis is mainly confirmed via ultrasound, which shows thickening of the appendix wall (≥2 mm), the presence of abnormal intraluminal fluid mixed with gas, and peritoneal reactivity. Timely intervention is critical for a positive outcome. This retrospective study included all rabbits presented to CVS Clinic (Rome), from 2022 to 2024, that were ultrasonographically diagnosed with appendicitis. Medical management was found to be effective in treating rabbits with acute appendicitis. In the described cases, an early diagnosis was associated with a better outcome. This retrospective study analyzes the effectiveness of medical therapy for appendicitis in rabbits, focusing on treatment methods, timing, and resolution outcomes. In conclusion, medical management can be a viable option for the treatment of appendicitis in rabbits, particularly where surgical intervention is not feasible or when the condition is diagnosed at an early stage.