As is the case with other exotic companion mammals, guinea pigs are commonly diagnosed with bacterial infections. These infections can occur in multiple body systems and at various time points throughout the life of a guinea pig. We reviewed microbial culture and sensitivity data from clinically ill guinea pigs processed by a university diagnostic lab over a 5 year period (2019-2023). In total, 235 cultures were evaluated for this population. Data was extracted from the culture reports, including the age and sex of the guinea pigs, culture site, bacterial identification, and sensitivity data for each cultured bacteria. The most common bacterial isolates included Corynebacterium renale, Streptococcus spp., and Staphylococcus aureus. Antimicrobial resistance will be reported for isolates after final data analysis. This research is currently in the final steps of data analysis and will be completed by the end of December. Results will be shared in the formal conference abstract.