Orthopedic surgery in rabbits presents challenges due to their unique bone structure, characterized by low bone density, high mineral content, and thin cortical bone. These factors make rabbit bones particularly prone to fractures, especially in the tibia. Common fracture repair techniques in small animals include external coaptation, intramedullary pins, bone plating, and external skeletal fixation. Among these, the plate-rod technique offers excellent stabilization and load-bearing support. An 8-month-old male Flemish Giant rabbit (4.6 kg) presented with a traumatic injury resulting in an inability to use its right hind limb. Physical examination revealed lameness, misalignment, and crepitus of the right tibia. Radiographs showed a closed, comminuted fracture of the distal tibia. Due to the complexity of the fracture, high-resistance implants were necessary for stabilization. Surgical intervention was performed under general anesthesia using dexmedetomidine, tramadol, ketamine, alfaxalone, and isoflurane. Open reduction and internal fixation (ORIF) was achieved using a retrograde intramedullary pin and a 2.0 titanium locking plate with four locking screws and one cortical screw. Postoperative care included antibiotics and anti-inflammatory medications. Two weeks post-surgery, callus formation was observed, and by 8 weeks, the rabbit was hopping with both hind limbs. Radiographs showed proper bone alignment and remodeling by 3-4 months. There were no implant-related complications, and the rabbit fully resumed normal activity. The plate-rod technique proved effective for tibial fracture stabilization in giant rabbits.