Let’s be honest, approaching euthanasia in zoological companion animals can be a bit daunting, especially if exotic animal medicine is not the primary focus of your practice. This masterclass concentrates on a practical approach to euthanasia of ectotherms (reptiles, amphibians, fish) and exotic companion mammals. We will discuss recommended techniques (including how to glean the information you need from the AVMA euthanasia guidelines), species-specific tips and tricks, useful drugs and equipment to have on hand, and the influence of unique anatomic and physiologic features.