The masterclass will introduce the basic concepts and the science of apitherapy in the first hour and then it will focus on clinical cases where apitherapy was used in a variety of exotic animal patients. While Apitherapy or the use of honey bee byproducts is not a novel idea and has been used for thousands of years in human medicine, very little is known about the mechanisms of actions. This is most likely the reason why this exciting field in medicine is often not very well accepted in western medicine and often considered ‘quackery’. The first part of the workshop aims to provide more insight into the variety of mechanisms on how honey, venom and propolis can have beneficial effect in the affected patient. A few examples on how the apitherapy is used in animal patient are shown and what kind of research is conducted at UGA in this field. Each case contributed to the ever growing and exciting field of clinical apitherapy and hopefully we can continue to learn more about the in vivo application of bee venom, honey and other products to the benefit of affected animals and then translate the knowledge to even human medicine. While a lot of information on apitherapy originates from in-vitro experiments or even human case reports, the exchange of information between practical veterinary apitherapy and human apitherapy can only be beneficial for all parties involved and thereby moving the science forward.