A male 12 gram six-month-old panther chameleon (Furcifer pardalis) was presented. Preliminary history included treatment with repeated subcutaneous injections two months before due to persistent inappetence, and tongue shooting problems. Immediately after the last treatment by the previous vet, the owner noticed a pinhead-sized UV on the right body side, which grew to the size of half a hazelnut. Initially this UV was retracted on its own, but since the molting six days before presentation, the UV had increased considerably in size and was now permanently visible. Clinical examination revealed retarded development and a respiratory associated extensive protrusion of the right coelomic wall. Dorsoventral radiographs showed a unilateral homogeneous structure with air opacity at the right subcutaneous coelomic wall. Air was aspirated subcutaneously on the coelomic wall, but shortly, the right-sided protrusion reappeared. The owner agreed on surgery despite the high risk. The chameleon was premedicated with analgetics (Carprofen 4 mg/kg sc) and underwent general anesthesia with isoflurane. A defect of the intercostal muscles on the right side was visible intraoperatively, and parts of ventilated lung tissue were prolapsed through the hernia of the coelomic wall. The non-reducible prolapsed ventilated tissue was ligated, surgically removed, and the remaining tissue was translocated back into the coelomic cavity. Intercostal muscles and skin were sutured. Recovery was uneventful. No further abnormal subcutaneous gas accumulation was visible. To the author's knowledge, this is the first description of an iatrogenic induced lung prolapse / hernia in a panther chameleon (Furcifer pardalis) and its successful therapy.