Clinical signs of renal disease in snakes are reported as vague. Monitoring changes in snake body posture has been proposed to assess snake welfare and health, but the impact of renal disease on reptile posture is currently unknown. As part of larger experimental trial, acute renal tubular necrosis was induced in six adult corn snakes (Pantherophis guttatus) with gentamicin 50 mg/kg SC q24h for 11 days. A standard environment was provided in terraria (warm side at 31°C; cold side at 28°C). Video recordings of each individual were conducted in time lapse mode. Renal health was assessed by renal biopsy and biochemistry panels once a week. Activity, posture, selected instantaneous behaviors, and preferred location in the terraria were evaluated by two observers using a commercial software (ZooMonitor). Three postures were evaluated: curled, semicurled (<50% body rectilinear) and rectilinear body positions. Linear mixed models were used with the posture as independent variable, the time as dependant variable and the individual snake and observer as random variables. A semicurled body position was more prevalent (P = 0.01) in individuals with renal lesions compared to baseline. A curled body position was more prevalent (P = 0.0004) at baseline (mean: 27% time) than after induction of renal lesions. Over time, feeding delay increased significantly (P = 0.02). Activity levels did not change significantly from baseline. Snake location in the terrarium did not significantly differ between baseline and after renal lesion induction. In conclusion, body posture can be an indicator of renal disease in colubrids.