Abastract Chrysosporium Anamorph of Nannizziopsis vriesii (CANV) is a collection of fungi of the genera Nannizziopsis, Ophidiomyces and Paranannizziopsis. CANV has resulted in a variety of skin lesions such as necrosis and ulcers in reptiles and continuously affected both captive and wild reptiles’ health. Follow up the finding of confirmed case of Ophidiomycosis in Taiwan. We examined 2382 wild snakes in Taiwan representing 43 species, 132 (5.76%) snakes with skin lesions. Surgical biopsy on the lesions was performed to collect samples for fungal culture and histopathological diagnosis. The infections were confirmed by the presence of fungal elements in the tissue. The pathogens were identified based on their morphological and DNA sequence characteristics. 10 (0.42%) snakes representing 5 species were tested positive for Ophidiomyces (5) or a novel Nanninzziopsis (5). Infected snakes were generally healthy with minor clinical signs. As the author’s knowledge, this is the first large scale field study about the presence of CANV in Asia and first detection of natural infection of Nanninzziopsis in snakes in the field. The low prevalence rate, minor clinical signs and wide pathogen/host range may support the suspicion that Ophidiomyces are endemic in south east Asia.3 The finding of Nanninzziopsis in wild snake highlight the probability of spillover of former CANV fungi into additional naive hosts and may suggest a modification of surveillance strategy. Studies focus on molecular evolution of CANV and the distribution and susceptible species of Ophidiomyces / Nannizziopsis will be needed in the future.