Periodontal disease in lizards is becoming more and more common and has been treated as a distinct clinical entity in the last 15+ years. This condition is seen in chameleons and agamid lizards such as the inland bearded dragon (Pogona vitticeps), Chinese water dragon (Physignathus cocincinus), Uromastyx (Uromastyx spp.), and frilled dragon (Chlamydosaurus kingii). Bearded dragons appear to be markedly overrepresented, and as such a common pet species, periodontal disease is frequently encountered every day in veterinary practice. The reptile veterinarian should be familiar with how to recognize, diagnose, treat, and prevent periodontal disease in pet reptiles. This presentation will discuss the pathogenesis of periodontal disease in reptiles with acrodont dentition. It will also cover a proposed grading scale and proper diagnostic workup for this condition along with possibilities for treatment and long-term management. Prevention is key as with periodontal disease in domestic species, and several options will be presented.