A 5-year-old male intact central bearded dragon (Pogona vitticeps) presented to the Oklahoma State University’s zoological medicine service after referral from his primary care veterinarian for suspected trauma to the tail 8 days prior. The patient’s appetite, energy, urination, and defecation all decreased after the injury. Radiographs revealed several abnormal caudal vertebrae, including an acute, traumatic distal tail fracture, and multifocal chronic fractures with callus formation most consistent with metabolic bone disease. Tail amputation was elected due to the degree of pathology; however, some vertebrae with chronic changes were left behind due to their proximity to the tail base and associated structures. Sedation and intrathecal neuraxial anesthesia were selected for the procedure to aid in faster recovery compared to general anesthesia. The patient was sedated with subcutaneous midazolam (1 mg/kg) and dexmedetomidine (0.1 mg/kg). This resulted in marked sedation. The patient then received bupivacaine (1 mg/kg) and preservative-free morphine (0.15 mg/kg) intrathecally. The patient maintained an adequate plane of local anesthesia with this protocol and the tail was amputated 7.5 cm from the tail base using the radiographs for surgical planning. Samples were submitted for microbial DNA sequencing and histopathology, ruling out infectious and neoplastic etiologies. Recovery was uneventful and resulted in the patient eating and returning to normal energy levels within 24 hours of the procedure. The patient died 9 weeks later due to unrelated disease. Intrathecal neuraxial anesthesia should be considered as an alternative to general anesthesia for management of tail amputation in reptiles with similar presentations.