A 3 year old Finlayson's squirrel presented in 2021 with a right forelimb severe infection and bite self trauma, this forelimb was amputation in first treatment. The next 3 months this case came back with a left hindlimb deep ulcer wound which was treatment by wound management along 2 months this was subsequently diagnosed the autoimmune disease and drug eruption by skin punch biopsy then decided to treatment by prednisolone, antibiotic and laser therapy. The results of this case was success and have no any side effects. However, there are still relatively few reports of using prednisolone in squirrels.