Rabbit anesthesia is drastically different than anesthesia of domestic carnivores. Rabbits have a strikingly higher peri-anesthetic mortality as compared to dogs and cats. One of the challenges to select proper anesthetic protocols in rabbits is the fact that most published research studies include populations limited in numbers and procedures, making difficult to generalize their results to clinical patients. In the current presentation we are going to discuss available protocols, including the ones that have been used with greater success by the authors, and best practices, such as reducing stress, multimodal analgesia, airway and vascular access, to minimize the risk of anesthetic-related mortalities in rabbits.