Background-Rabbits are at a higher risk of anesthetic complications, includingmortality, compared to dogs and cats. The largest study on peri-operativemortality showed a 24-hour mortality rate of 3.9% (7/178) for rabbitsundergoing general anesthesia, with 42.8% (3/7) rabbits dying during induction.Historically, rabbit induction has been performed with anesthetic gasses and thereare limited reports of the use of propofol in clinical practice. The objectivesof our study were to compare the usage of propofol versus gas anesthetic inclient-owned rabbits in terms of their mortality rate and peri-anestheticcomplications. Methods-All the rabbits that had general anesthesia inducedwith propofol between January 2021 and March 2023 by the exotics service of aveterinary teaching hospital were included in this retrospective case series. Results-A total of 57 rabbits were included. Rabbits wereanesthetized for a variety of procedures, ranging from elective (eg ovariohysterectomy)to emergent procedures (eg gastrointestinal obstruction, liver lobectomy). Meanage was 3.6 years (range, 0.4 to 9.0 years) and mean body weight was 2.7 kg (1.3to 6.6 kg). Rabbits received a variety of premedication agents including midazolam,ketamine, dexmedetomidine and/or opiates. Amount of propofol required forintubation ranged from 0.5 to 9 mg/kg. Total anesthetic duration time was 123minutes (range, 25 to 273 minutes). A total of 1 rabbit died during or in the24 hours following the anesthetic event (mortality rate: 1.8%, 95% CI: 0.0 to 5.2%).Conclusions-Induction with propofol is safe in client-owned rabbitsundergoing a wide range of procedures.