Plasma biochemistry values such as glucose and blood urea nitrogen are essential for monitoring guinea pig health. Guinea pig phlebotomy can be challenging, especially in non-sedated animals. Point-of-care (POC) analyzers and strips can measure chemistry analytes using 0.1 ml blood or less and may be an alternative when larger blood volumes are unavailable. However, in many species, significant differences exist between POC analyzers and traditional benchtop methods. Assessment for analytical and clinical agreement is recommended prior to use in each species. Samples from 14 adult guinea pigs were obtained weekly. Blood was analyzed on a traditional benchtop analyzer, the portable Abaxis VetScan VS2 (glucose, blood urea nitrogen, ALT, ALP, creatinine, and total protein), 3 glucometers (AlphaTrak II canine setting, AlphaTrak II feline setting, Accucheck; glucose), and using Azostix (blood urea nitrogen). Methods comparison assessments will be performed for all 6 analytes using repeated measures, with the traditional benchtop analyzer as the gold standard. Statistical analyses will include Spearman correlation coefficient, difference plots, and Block-Passing-Bablok regression. A linear regression model will be used to investigate potential effect of hematocrit. Recommendations for clinical application of POC analyzers and strips in guinea pigs will be presented (final data analysis pending).