Plasma protein electrophoresis (EPH) is a valuable tool for health assessment in reptile patients, with agarose gel electrophoresis (AGE) historically used and capillary zone electrophoresis (CZE) emerging as a promising alternative. This study aimed to characterize changes in AGE and CZE EPH profiles during convalescence in rehabilitating eastern box turtles (Terrapene carolina carolina). Twenty-five adult eastern box turtles admitted for rehabilitation were categorized by presenting complaint as suspected infectious disease, trauma, or other. Blood samples for CBC, AGE, and CZE were collected at admission, one-month post-admission, and at release. Enrollment and sample analysis are ongoing. Preliminary results indicate that turtles presenting with suspected infectious disease (N = 7) exhibited electrophoretic patterns consistent with chronic inflammation, including decreased albumin-related parameters and increased gamma globulin and late CZE fractions (p < 0.05). In contrast, turtles presenting with traumatic injuries (N = 16) showed evidence of acute inflammation, characterized by increased alpha-1 globulins (p = 0.04). Turtles admitted for other reasons (N = 5) demonstrated similar but less pronounced changes than infectious turtles. Across all presenting categories, several parameters changed significantly during rehabilitation regardless of initial diagnosis, including decreases in albumin-related measures and increases in alpha-2 globulins and early CZE fractions (p < 0.05). Nine turtles died or were euthanized during rehabilitation, and no electrophoresis parameter significantly predicted mortality (p > 0.05). Despite variability in EPH patterns by clinical presentation, both AGE and CZE revealed consistent changes during rehabilitation, indicating that either method can provide useful information for clinical case assessment and monitoring.