Insect and Cricket “water crystals”, “quenchers” and “hydration crystals” are marketed by reptile supply companies as safe, non-toxic products, with the benefits of reducing bacterial contamination, preventing the drowning of insects and as a source that can be fortified with nutrients for prey items fed to pet reptiles which may inadvertently give owners a sense that these products are innocuous to their reptiles as well. These polymer gels initially start as small dehydrated crystalline granules that then may expand up to 400 times upon hydration. This material is not broken down by gastric acid and may lead to blockage in animals with smaller intestinal lumens. Reptiles are often presented practitioners for gastrointestinal signs like anorexia, diarrhea, vomiting/regurgitation, with common etiologies being poor diet and husbandry conditions, parasitism, Cryptosporidium spp infections, and gastrointestinal impaction by substrate. Another differential to be considered is intestinal obstruction with polyacrylamide gel. This substance has been reported as a risk when used in other products to birds and small children, but not yet published in small reptiles. Case descriptions: Two leopard geckos (Eublepharis macularius) presented to a specialty exotic animal hospital due to regurgitation and weight loss. Semi-firm masses were palpated within the stomach lumen of each patient. The first case received a successful gastrotomy removing the material. The second case resulted in humane euthanasia and discovery of the crystalline gel within the coelomic cavity concurrent with a gastric perforation. Intestinal obstruction had occurred secondarily to ingestion of dehydrated particles of polyacrylamide gel in each case.