Multilobular tumor of the bone is a rarely described in the ferret. In this case, a 2-yr-old, male neutered was ferret presented for an oral swelling. On physical examination, a firm swelling was noted surrounding the base of tooth 409 with no discharge. The remainder of the physical examination was unremarkable. Differential diagnoses included oral neoplasia or abscess. A biopsy was recommended with possible extraction of the of the affected tooth. Medical was initiated and a biopsy was scheduled. In surgery, the mass was determined to be firm. The initial biopsy results indicated a chondrosarcoma. A hemimandibulectomy was recommended and scheduled. The surgery was successful without complications. The final histopathology report showed a multilobular tumor of bone. At 8 months post-operative and at the time of writing, no recurrence had been noted. This case reports an unusual presentation of a mandibular swelling in a ferret. Although rare, a multilobular tumor of bone should be considered as a differential for mandibular swelling in ferrets. Surgery intervention may be a viable treatment option, although long term-survival intervals are not known.